Most people talk about having two monitors hooked up to their computer. Well I have two mice hooked up to mine; one on each side of the keyboard. Why do I have two mice you might ask? Well there are times when I like to use a mouse with my left hand and times when I like my right. Copy and pasting things requires use of the right mouse because the left hand is busy with CTRL, X, C and V keys. Use the number pad and I use the left mouse. Someone else comes into my office and wants to drive and we don't have to fight over a mouse, we each got one. Give it a try. I guess you have to be ambidextrous first. It just takes some practice.